Resolume can use multiple displays to show different content on different screens. You can show different content on the displays by routing different layers or layer combinations to different displays. This way you can for instance show the resolume interface (with a small preview) on a monitor in front of you. And then show the combination of layer 1&2 on projector 1 and show layer 3 on projector 2. Or if you have 4 displays you can use one for the interface and send the 3 different layers to 3 different projectors.