ive had the same problem. it's pretty annoying huh?
i read in another post that disabling aero on the desktop helps with screen problems.
so yeh i tried that, by right clicking the desktop and choosing personization, then the windows basic theme.
resolume still doesnt seem to like it if fullscreen output is set to the same display as the interface, but worked fine for me outputting to another screen.
ps. i am running win 7 home, resolume 4.1.1, and a 7970m graphics card with the catalyst 12.8 drivers.
hope thats some help untill it gets sorted..