A reeeeally helpful feature would be the ability to store/assign blend mode settings on a per clip/column basis. This way you could program really dialled in looks that include different blend modes, store/assign them to a clip/column and then recall those settings by simply triggering that clip/column. This is the biggest hurdle I see when quickly programming looks for a very linear show (a bands set list, look per song, etc).
Essentially, the idea is to build a look and be able to recall it without having to manually change a bunch things like blend modes and layer order to fully recall that look.