It's interesting to see how people jump to custom content and layer to slice routing, when confronted with something which is not 4:3 shaped
It's actually very easy to mix your own content on panels like this. In fact, it's what we make Resolume for.
Just keep your regular composition size and load all your regular clips. Keep 1 or 2 layers as they are, you can use these to mix on the background.
Take another 1 or 2 layers and scale these so they cover the top 2/3rds of your comp. Just scale them down to around 66% and position them up along the Y axis. This way your content will not get distorted.
For the bottom panel, take another 1 or 2 layers. Scale them down to 66% as well and position them so their center is 1/3rd from the bottom. You'll need to use a crop effect to cut off the part that would appear on the back panel. This will cause you to lose parts of your content, but that can't be helped with screens of this shape. You can still play DJ names fine on it.
This way your comp is ready to go. Layer 1/2 cover the whole screen, layer 3/4 only show up on the back panel, layer 5/6 only on the front panel. Of course you can use more or less layers for each group. The principle is the same.
In the advanced output, all you need to do is take a slice which covers the center of the comp in a 3x4 aspect ratio, and is scaled to fit the input of the led processor. Depending on the processor setup, you might need two slices for each panel, but for such a simple setup, I think 1 slice will work just fine.
So all the magic happens in the composition! Hope that makes things a bit simpler for you guys and that you can focus on VJ'ing instead of coming up with elaborate output setups or making all your content custom.
Btw, I'm guesstimating the 66%, you'll need to eyeball this yourself. Just make sure your back panel layers cover the entire height of the back panel. A little might 'fall off' on the sides, it's hard to predict without knowing the pixel resolution of the screen.