I had the same issue on MSI GE63 Raider 8RF RGB. When using external output (HDMI or DP) the screen going in white and Resolume freezing. Windows 10 (1803) with the latest Intel and Nvidia video drivers. I can't install Windows 7 cause hardware and other software issues. The trick with change main screen working, but it's very harmful when needed add new content on fly. I find the temporary solution: run Resolume, go to output, click on main ( not external display) WINDOWED, and than just drag and drop by mouse output window to the external screen. Then use fine tunning with keyboard's arrow keys.
But I wont to know, who make this trouble: Intel, Nvidia, MSI, Microsoft or Resolume?
Other softwares works fine (besides Arkaos GrandVJ freezing when I use "Force resolution" options). So, this is not Intel's, Nvidia's or Microsoft's issue. I have an another MSI laptops GE72 7rg and GE62 7rg and they working fine with Resolume 6. So this is, probably, not MSI's issue.