A Wire patch loaded in Avenue, will use the OSC ports set in Avenue preferences. Basically the patch says, hey, Avenue, send this OSC packet for me. Similarly for receiving, Avenue will say, hey Patch, I got this OSC packet, do you want to do anything with it?
If you have Wire open though, then open Avenue, they won't be able to use the same ports, because the first will block it for the second.
Maybe this was the original cause of the issue?