I ran a system with an M6000 in it for a few months, before realizing that something in the Quadro driver throttles the GPU specifically with Resolume.
We ran the Resolume Benchmark with the NVIDIA GPU monitor open and found that that usage would plateau at 33%. 4K Benchmark was somewhere around 6-7 layers. We then switched to a Titan X, and got phenomenally better performance. 4K Benchmark went to 16 layers.
I'm no expert but it might be in the way that the Quadro driver uses OpenGL is different from how Resolume does, or the GeForce driver does. It could also be that the GPU identifies Resolume as a 32-bit program and then doesn't allocate full VRAM.
All just guesses. GeForce over Quadro for Resolume every and any day of the week.