Ableton does this on my APC 40 by sending the note feedback also on a different channel.
I guess that's how the launchpad works also.
You can trick your controller into this mode with Resolume by
duplicating your clip launch shortcut, and
on the shortcut on the right(top in the list), setting Connected state velocity to a different color, and
setting the Channel to 11 for example.
For an effect bypass it can work similarly. These have an On and an Off state. On state is sent when an effect bypass is On, so the effect is disabled.
If you'd like the button on your controller to blink when an effect is On, (bypass is Off), you'd map your controller button to the effect bypass, set the Velocity for the On and Off Status to the base color you'd like for them.
Then, duplicate the shortcut, select the shortcut that's the upper one in the shortcuts panel list.
Set it's channel to 11 (slow pulse) for example, and set the Off Status Velocity to a different color value.
If you exit shortcut editing the button should blink if the effect is unbypassed.