you mention MOVs but have you encoded in DXV?
I have one come where the banks load but the first one plays crazy super slow. Other banks ok. Happens on mac and pc. Only this one comp that this happens in.
is it the fps that is dropping? What resolution are you working at?
So this composistion has the same performance on different machines?
Is it just one particular clip? you could maybes render it out again and see if this fixes it.
Resolume Avenue 3.3.3 - MBP i7, 8gb RAM - Snow Leopard (2010). Akai APC20