The only thing you would need.to keep in mind is your PCIe lane count that your CPU can handle. With that many I/O's you're going to run out of I/O pretty quick.
After buying a multi Xeon setup, your I/O cards. There might be a better solution out there as Angelo has brought up.
I'm all for using Resolume in any aspect of my production that I can. But this might be a good time to write down a pros and cons list. Including price and what people ask for when renting out gear and see if going this route is the right option.
Can Resolume do it? totally. Will you be the only person who knows how to get your frankenstein setup to work? Probably.
I'm here to help if you need it